General Information

  • ID:  hor002557
  • Uniprot ID:  A0A7M7GM99
  • Protein name:  Neuropeptide like precursor 1
  • Gene name:  LOC100577694
  • Organism:  Apis mellifera (Honeybee)
  • Family:  NA
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Apis (genus), Apini (tribe), Apinae (subfamily), Apidae (family), Apoidea (superfamily), Aculeata (infraorder), Apocrita (suborder), Hymenoptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  NA

Sequence Information

  • Sequence:  NVASLARTYTLPQNA
  • Length:  15
  • Propeptide:  MVEMAYIRKLTRTLPVLRFGEPHWEDISDLVCEMGLTGNHLVTLLLYVAVVNEIRLPLVTCQDEDSTQCMPKTAFLALLRHPEVSSSLAAYSRAARVTQDTKSRNDMAHLRALTEEGDDTEICVPGRVYLQLLKDPVVRGDLSAILNGRTQKVPDLLGRLIDDTDQMDAREYPFEYQKRSIATLAKNDDLPISLHDRMAENEDDEEKRAVISSSDHSIIRDYLPPNGRSEEQALRDFSMEKRNVGTLARDFALPPGRRNIASLMRDYDQSRENRVPFPGKRNVASLARTYTLPQNAGKRNVGSVAREHGLPYGKRYVASLARTGDLPIRGQRSVSSLARTGDLPVREQRSVSSLAKNSAWPVSLKRGIFLPGSVILRALSRQGRSFDSADTNARNDLLDLQALGNLRQSQENDYESEEKVNDSLKADSNIRRSKREIAFSDEYPLPVMQNANMFDYEEMMEALGGQYPNAEKRFMGTGSAPEMQPEVDQFGYPETFQANKRHIGALARLGWLPSLRTARFSRSPRYLVDRENPADGSSPNYSSNSSTRSLRPNLNPRTRYIQALHGDCRHGFKRFLLLPATDNNYFHQKLPSSLRSKSL
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-A0A7M7GM99-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor002557_AF2.pdbhor002557_ESM.pdb

Physical Information

Mass: 186871 Formula: C70H115N21O23
Absent amino acids: CDEFGHIKMW Common amino acids: A
pI: 9.35 Basic residues: 1
Polar residues: 6 Hydrophobic residues: 6
Hydrophobicity: -19.33 Boman Index: -2311
Half-Life: 1.4 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 91.33
Instability Index: 2935.33 Extinction Coefficient cystines: 1490
Absorbance 280nm: 106.43

Literature

  • PubMed ID:  19576913
  • Title:  Mass Spectrometric Profiling of (Neuro)-Peptides in the Worker Honeybee, Apis Mellifera